Diphosphonate intermediate for preparing an antihypercalcemic ag

Details Diphosphonate intermediate for preparing an antihypercalcemic ag Diphosphonate intermediate for preparing an antihypercalcemic ag

1990-09-18

1991-08-13

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07F 940

Patent

active

050398199

ABSTRACT:
Described is a new diphosphonate intermediate useful in a new process for producing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP), a new antihypercalcemic agent. The process involves a 3-step sequence starting with 4-phthalimidobutanoyl chloride which can be practiced as a "one-pot" reaction sequence, without employing PCl.sub.3 or H.sub.3 PO.sub.3. The new intermediate has the structure: ##STR1## where n=1-5.

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