Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1985-06-28
1989-05-16
Terapane, John F.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, 534 14, 2605025C, 2605024P, 514108, 514 6, 530345, 530400, 530402, 530409, A61K 4300, C07F 1700, C07F 938
Patent
active
048308471
ABSTRACT:
Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromolecules. Also disclosed are pharmaceutical compositions containing these diphosphonate-derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.
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Benedict James J.
Degenhardt Charles R.
Poser James W.
Caress Virginia B.
Dabbiere David K.
Graff IV Milton B.
Schaeffer Jack D.
Terapane John F.
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