Diphosphate salt of a 4″—substituted-9-deoxo-9...

Details Diphosphate salt of a 4″—substituted-9-deoxo-9... Diphosphate salt of a 4″—substituted-9-deoxo-9...

2007-11-20

2007-11-20

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S007200, C536S007400, C536S007500

Reexamination Certificate

active

10840529

ABSTRACT:
This invention relates to a novel crystalline diphosphate salt of (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopryanosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one that is useful as an antibacterial and antiprotozoal agent in mammals. This invention also relates to pharmaceutical compositions containing the free base of the diphosphate salt and the methods of treating bacterial and protozoal infections in mammals by administering the free base of the diphosphate to mammals requiring such treatment. The free base of the diphosphate salt of the present invention possesses potent activity against various bacterial and protozoal infections when given by parenteral application to mammals.

REFERENCES:
patent: 6465437 (2002-10-01), Rafka et al.
patent: 6861412 (2005-03-01), Rafka et al.
patent: WO 98/56802 (1998-12-01), None

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