Diphenylurea derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514587, 514596, 514598, 564 28, 564 29, 564 52, 564 53, 564 54, A61K 3117, C07C33518, C07C27534

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active

050632477

ABSTRACT:
Novel diphenylurea derivatives represented by the following formula (I): ##STR1## wherein R.sub.1 is an alkyl group of 5 to 18 carbon atoms, each of R.sub.2 and R.sub.3 is independently an alkyl group of 1 to 5 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, R.sub.4 is hydrogen atom, an alkyl group of 1 to 5 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, and X is oxygen atom or sulfur atom, are provided.
The compounds are potent in reducing the cholesterol level in serum, and useful for treating hyperlipemia and atherosclerosis.

REFERENCES:
patent: 3579578 (1971-05-01), Nikawitz et al.
patent: 3860645 (1975-01-01), Nikawitz
patent: 4218438 (1980-08-01), Callender et al.
patent: 4387105 (1983-06-01), De Vries et al.
patent: 4405644 (1983-09-01), Kabbe et al.
patent: 5003106 (1991-03-01), De Vries
Callender et al., "Anticoccidial Composition and Carbanilides", CA 94, 71498v (1981).

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