Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-07-25
1991-04-09
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5482622, 5482674, A61K 3141, C07D24908
Patent
active
050065432
ABSTRACT:
Diphenylethane derivatives of the formula ##STR1## are described; wherein R.sup.1 is a heterocyclyl radical selected from the group consisting of 1,2,4-triazolyl, optionally-substituted imidazolyl, pyridyl and pyrimidinyl radicals; R.sup.2 and R.sup.3, which may be the same or different, are each a hydrogen atom or a 1-6C alkyl radical; R.sup.4 and R.sup.5, which may be the same or different, are each a hydrogen or fluorine atom or a 1-6C alkyl radical; and A is a phenyl radical, optionally bearing one or more substituents selected from halogen atoms, cyano radicals or 1-4C halogenoalkyl or halogenoalkoxy radicals. Processes for their preparation are described, as is their use as aromatase inhibitors, for example in the treatment of cancer or as plant antifungal compounds.
REFERENCES:
patent: 4598085 (1986-07-01), Hares et al.
Imperial Chemical Industries plc
Lee Mary C.
Morris Patricia L.
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