Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen

Details Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen

1993-08-16

1994-06-28

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 546236, 544336, A61K 31445, A61K 31495, C07D21120

Patent

active

053247361

ABSTRACT:
Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes substituents comprising a hydroxy group, a hydrogen atom, an acetate group or a substituted or unsubstituted alkoxy group. The compounds are useful as antiestrogens and anti-tumor agents.

REFERENCES:
Hausser et al., "Solvolysis of Cyclopropyl Halides. III. 2,3-Diphenylcyclopropyl Chlorides", J. Org. Chem., 37:4087-4090 (1972).
Magarian et al., "2-Chloro-1-phenylindene from 1,1-Dichloro-trans-2,3-diphenylcyclopropane", J. Pharmaceutical Sciences, 61:1216-1219 (1972).
Magarian et al., "Synthesis of Cyclopropyl Analogs of Stilbene and Stilbenediol as Possible Antiestrogens", J. Phar. Sci. 64:1626-1632 (1975).

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