Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen

Details Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen Diphenylcyclopropyl analogs as antiestrogenic and antitumor agen

1994-02-25

1995-06-06

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514650, 558 46, 558 47, 558 51, 564338, H61K 31225, A61K 31135, C07C21746, C07C30911

Patent

active

054223679

ABSTRACT:
Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes substituents comprising a hydroxy group, a hydrogen atom, an acetate group or a substituted or unsubstituted alkoxy group. The compounds are useful as antiestrogens and anti-tumor agents.

REFERENCES:
patent: 3646146 (1972-02-01), Teotino et al.
Hausser et al., "Solvolysis of Cyclopropyl Halides. III. 2,3-Diphenycyclopropyl Chlorides", J. Org. Chem., 37:4087-90 (1972).
Magarian et al., "2-Chloro-1-phenylindene from 1,1-Dichloro-trans-2,3-diphenylcyclopropane", J. Pharmaceutical Sciences, 61:1216-19 (1972).
Magarian et al., "Synthesis of Cyclopropyl Analogs of Stilbene and Stilbenediol as Possible Antiestrogens", J. Phar. Sci. 64:1626-32 (1975).

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