Diphenylcyclopropyl analogs

Details Diphenylcyclopropyl analogs Diphenylcyclopropyl analogs

1995-06-07

1997-08-19

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514651, 514709, 514710, 514711, 514717, 514736, 558 44, 558 51, 558 53, 564306, 568583, 568629, 568647, 568655, 568774, 568775, 568807, A61K 31135, A61K 3110, C07C30100, C07C 4320

Patent

active

056589514

ABSTRACT:
Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes alkoxy substituents including a dialkylaminoalkoxy group, an unsubstituted piperazine alkoxy group, a substituted piperazine alkoxy group, an unsubstituted piperidine alkoxy group, and a substituted piperidine alkoxy group, and which may have one or two alkyl groups bonded to the cyclopropane. The compounds are useful as antiestrogens and anti-tumor agents.

REFERENCES:
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patent: 5015666 (1991-05-01), Magarian et al.
patent: 5098903 (1992-03-01), Magarian et al.
patent: 5324736 (1994-06-01), Magarian et al.
patent: 5397802 (1995-03-01), Magarian et al.
patent: 5422367 (1995-06-01), Magarian et al.
Day et al., "Synthesis and Biological Evaluation of a Series of 1, 1-dichloro-2,2,3-triarylcyclopropanes as Pure Antiestrogens", Journal of Medicinal chemistry, 1991, vol. 34, No. 2, pp. 842-851.

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