Diphenyl pyridyl ethane derivatives as PDE IV inhibitors

Details Diphenyl pyridyl ethane derivatives as PDE IV inhibitors Diphenyl pyridyl ethane derivatives as PDE IV inhibitors

1996-12-10

1998-01-20

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514255, 514340, 514357, 514396, 546266, 5462727, 548203, A61K 3144, A61K 3140, C07D21353, C07D23504

Patent

active

057101604

ABSTRACT:
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.

REFERENCES:
patent: 4882343 (1989-11-01), Cordi
patent: 5580888 (1996-12-01), Warrellow
The Merck Index; S. Budavari (Ed.); 12th Edition: "An encyclopedia of chemicals, drugs, and biologicals" 1996, Merck Research Laboratories, Whitehouse Station, N.J. ISBN 0911910-12-3 XP002027526, See monograph 8410.
Chemical Abstracts #125:132083 by Gozzard, 1996.
Chemical Abstracts #125:158239 by Holbrook, 1996.
Chemical Abstracts #125:185440, 1996.
Chemical Abstracts #124:260848, 1995.
Chemical Abstracts #124:260846, 1995.
Chemical Abstracts #123:286011, 1995.
Chemical Abstracts #122:265044, 1994.

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