Diphenyl-cyclopropenes as selective K-agonists

Details Diphenyl-cyclopropenes as selective K-agonists Diphenyl-cyclopropenes as selective K-agonists

1999-05-07

2000-02-01

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C 69743

Patent

active

060205199

ABSTRACT:
The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome, and stroke.
The compounds are K-agonists which are centrally acting and peripherally selective acting.

REFERENCES:
Kartashov et al., Steroechemistry, kinetics and mecchanism of the mercuration of . . . cyclopropene-1-carboxylates, Zh. Org. Khim 27(12), pp. 2490-2508, Dec. 1991.

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