Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents

Details Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents

1996-07-11

1997-10-14

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548127, A61K 3138, C07D28506

Patent

active

056773188

ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
patent: 4166452 (1979-09-01), Generales, Jr.
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen et al.
patent: 5401765 (1995-03-01), Lee
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 5536752 (1996-07-01), Ducharme et al.
patent: 5550142 (1996-08-01), Ducharme et al.
CA 124:2020589 Synthesis . . . heterocycle. Gautheir et al., p. 997, 1996.

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