Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-05-06
2008-05-06
Kosar, Andrew D. (Department: 1654)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S530000
Reexamination Certificate
active
11481349
ABSTRACT:
The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for treating conditions mediated by DPIV or DPIV-like enzymes, such as cancer and tumors. In a more preferred embodiment, the compounds of the present invention are useful for the treatment of metastasis and tumor colonization.
REFERENCES:
patent: 2961377 (1960-11-01), Shapiro et al.
patent: 3174901 (1965-03-01), Sterne et al.
patent: 3879541 (1975-04-01), Kabbe et al.
patent: 3960949 (1976-06-01), Ahrens et al.
patent: 4028402 (1977-06-01), Fischer et al.
patent: 4935493 (1990-06-01), Bachovchin et al.
patent: 5433955 (1995-07-01), Bredehorst et al.
patent: 5462928 (1995-10-01), Bachovchin et al.
patent: 5512549 (1996-04-01), Chen et al.
patent: 5543396 (1996-08-01), Powers et al.
patent: 5552426 (1996-09-01), Lunn et al.
patent: 5614379 (1997-03-01), MacKellar
patent: 5624894 (1997-04-01), Bodor
patent: 5705483 (1998-01-01), Galloway et al.
patent: 5827898 (1998-10-01), Khandwals et al.
patent: 5877202 (1999-03-01), Bitonti et al.
patent: 5939560 (1999-08-01), Jenkins et al.
patent: 6006753 (1999-12-01), Efendic
patent: 6011155 (2000-01-01), Villhauer
patent: 6107317 (2000-08-01), Villhauer
patent: 6110949 (2000-08-01), Villhauer
patent: 6124305 (2000-09-01), Vollhauer
patent: 6172081 (2001-01-01), Damon
patent: 6201132 (2001-03-01), Jenkins et al.
patent: 6303661 (2001-10-01), Demuth et al.
patent: 6319893 (2001-11-01), Demuth et al.
patent: 6448282 (2002-09-01), Phillips et al.
patent: 6500804 (2002-12-01), Demuth et al.
patent: 6517824 (2003-02-01), Kohn et al.
patent: 6548481 (2003-04-01), Demuth et al.
patent: 6605589 (2003-08-01), Uckun et al.
patent: 7109347 (2006-09-01), von Hoersten et al.
patent: 2001/0025023 (2001-09-01), Carr
patent: 25 42 598 (1976-04-01), None
patent: 296 075 (1991-11-01), None
patent: 196 16 486 (1997-10-01), None
patent: 299 09 210 (1999-10-01), None
patent: 198 26 972 (1999-12-01), None
patent: 198 34 610 (2000-02-01), None
patent: 0 658 568 (1995-06-01), None
patent: 0 708 179 (1996-04-01), None
patent: 0 995 440 (2000-04-01), None
patent: 1 130 022 (2001-09-01), None
patent: 2085665 (1971-12-01), None
patent: 2696740 (1994-04-01), None
patent: 04-288098 (1992-10-01), None
patent: 04-334357 (1992-11-01), None
patent: WO 91/11457 (1991-08-01), None
patent: WO 91/16339 (1991-10-01), None
patent: WO 91/17767 (1991-11-01), None
patent: WO 93/01812 (1993-02-01), None
patent: WO 93/08259 (1993-04-01), None
patent: WO 93/20061 (1993-10-01), None
patent: WO 95/11689 (1995-05-01), None
patent: WO 95/15309 (1995-06-01), None
patent: WO 95/22327 (1995-08-01), None
patent: WO 95/29691 (1995-11-01), None
patent: WO 97/40832 (1997-11-01), None
patent: WO 97/45117 (1997-12-01), None
patent: WO 98/19998 (1998-05-01), None
patent: WO 98/22494 (1998-05-01), None
patent: WO 99/41220 (1999-08-01), None
patent: WO 99/41224 (1999-08-01), None
patent: WO 99/46272 (1999-09-01), None
patent: WO 99/61431 (1999-12-01), None
patent: WO 99/62914 (1999-12-01), None
patent: WO 00/01849 (2000-01-01), None
patent: WO 00/10549 (2000-03-01), None
patent: WO 00/53171 (2000-09-01), None
patent: WO 00/53596 (2000-09-01), None
patent: WO 00/58360 (2000-10-01), None
patent: WO 01/09169 (2001-02-01), None
patent: WO 01/32624 (2001-05-01), None
patent: WO 01/34594 (2001-05-01), None
patent: WO 01/62266 (2001-08-01), None
patent: WO 01/74299 (2001-10-01), None
patent: WO 01/89569 (2001-11-01), None
patent: WO 01/94310 (2001-12-01), None
patent: WO 01/97808 (2001-12-01), None
patent: WO 02/13821 (2002-02-01), None
patent: WO 02/20825 (2002-03-01), None
patent: WO 03/016335 (2003-02-01), None
patent: WO 03/070732 (2003-08-01), None
patent: WO 04/089366 (2004-10-01), None
Amasheh, et al.; “Electrophysiological analysis of the function of the mammalian renal peptide transporter expressed inXenopus laevisoocytes”;Journal of Physiology; (1997); 504(1): 169-174.
Ansorge, et al.; “Membrane-bound peptidases of lymphocytes; Functional implications”;Biomed. Biochim. Acta; (1991); 50(4-6); 799-807.
Arai, et al. “Synthesis of Prolyl Endopeptidase Inhibitors and Evaluation of Their Structure-Activity Relationships: In Vitro Inhibition of Prolyl Endopeptidase from Canine Brain”;Chem. Pharm. Bull.; (1993); 41(i): 1583-1588.
Ashworth, et al.; “2-Cyanopyrrolidides as Potent, Stable Inhibitors of Dipeptidyl Peptidase IV”;Bioorganic&Medicinol Chemistry Letters; (1996); 6(10): 1163-1166.
Augustyns, et al.; “Pyrrolidides: synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IV”;Eur. J. Ed. Chem.; (1997); 32: 301-309.
Badia-Elder, et al; “Effects of Neuropeptide (NPY) on Ethanol Intake and Anxiety in High and Low Alcohol Drinking (Hadi/Ladi) rats”;Purdue School of Science; (2000).
Bergmeier; “The Synthesis of Vicinal Amino Alcohols”;Tetrahedron; (2000); 56: 2561-2576.
Welch, et al.; “Medical Management of Non-Insulin-Dependent (Type II) Diabetes”;ADA—Third Edition; (1994); 3-4.
Campbell, et al.; “Sulphonylureas and metformin: efficacy and inadequacy”;New Antidiabetic Drugs; (1990); 33-51.
Chemical Abstract 115;1-Pharmacology; (1991); 115: 37.
Chemical Abstract 118;34-Amino Acids, Peptides, Proteins; (1993); 118: 933.
Chemical Abstract 126;7-Enzymes; (1997); 126(2): 241.
Deacon, et al.; “Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I are Rapidly Degraded from the NH2-Terminus in Type II Diabetic Patients and in Healthy Subjects”;Diabetes; (1995); 4: 1126-1131.
Deacon, et al.; “Degradation of Glucagon-Like Peptide-1 by Human Plasma in Vitro Yields an N-Terminally Truncated Peptide that is a Major Endogenous Metabolite in Vivo”;J. of Clinical Endocrinology and Metabolism; (1996); 80: 952-957.
Dodge, et al.; “Folding and Unfolding Kinetics of the Proline-to-Alanine Mutants of Bovine Pancreatic Ribonuclease A′”;Biochemistry; (1996); 35: 1548-1559.
Duncan; “Diseases of Metabolism: Detailed Methods of Diagnosis and Treatment”; (1964); 951-957.
Durinx, et al.; “Reference values for plasma dipeptidyl-peptidase IV activity and their association with other laboratory parameters”;Clin. Chem. Lab. Med.; (2001); 39(2): 155-159.
Edwards, et al.; “Synthesis and activity of NH2- and COOH-terminal elastase recognition sequences on cotton”;J. Peptide Res.; (1999); 54: 536-543.
Endroczi, et al.; “Dipeptidyl Peptidase IV (DP IV) and Superoxide Dismutase Activity in Thymus-Derived Lymphocytes: Effects of Inhibitory Peptides and ZN2=In Vitro”;Acta Physiologica Hungarian(1996); 75(1): 35-44.
Frohman, et al.; “Rapid Enzymatic Degradation of Growth Hormone-releasing Hormone by Plasma In Vitro and In Vivo to a biologically Inactive Product Cleaved at the NH2Terminus”;J. Clin. Invest.; (1986); 78: 906-913.
Gomez, et al.; “Relationship between endo- and expopetidases in a processing enzyme system: Activation of an endoprotease by the aminopeptidase B-like activity in somatostatin-28 convertase”;Proc. Natl. Acad. Sci. USA; (1988); 85: 5468-5472.
Goodman & Gilman's; “Hormone and Hormone Antagonists”;The Pharmacological Basis of Therapeutics Ninth Edition; (1996); 1510.
Gossrau; “Cytochemistry of membrane proteases”;Histochem J.; (1985) 17(7): 737-71
Gutniak, et al.; “Antidiabetogenic Effect of Glucagon-Like Peptide-1 (7-36) Amide in Normal Subjects and Patients with Diabetes Mellitus”;New England J. Med.; (1992); 326: 1316-1322.
Gutniak, et al.; “Subcutaneous Injection of the Incretin Hormone Glucagon-Like Peptide 1 Abolishes Postprandial Glycemia in NIDDM”;Diabetes Care; (1994); 17(9): 1039-1044.
Hahn, et al.; “Enzyme histochemical evidence for the presence of potential blood pressure regulating proteases in cultured villous explants from human first trimester placentae”;Acta
Demuth Hans-Ulrich
Hoffmann Torsten
von Hoersten Stephan
Kosar Andrew D.
Probiodrug (AG)
Sonnenschein Nath & Rosenthal LLP
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