Dipeptidyl peptidase IV from Xanthomonas maltophilia and process

Details Dipeptidyl peptidase IV from Xanthomonas maltophilia and process Dipeptidyl peptidase IV from Xanthomonas maltophilia and process

1996-07-19

1998-09-22

Weber, Jon P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 711, 435 712, C12N 948, C12P 2104

Patent

active

058112782

ABSTRACT:
Dipeptidyl peptidase IV obtainable from a microorganism of the species Xanthomonas maltophilia is described, which hydrolyzes specifically a peptide and derivatives thereof having proline at the second position from the amino terminus to release a dipeptide having proline at the carboxyl terminus. Also, the process for producing the dipeptidyl peptidase IV is described.

REFERENCES:
Journal of Bacteriology, vol. 174, No. 8, pp. 2454-2459, Apr. 1992, E. Szwajcer-Dey, et al., "Proline-Specific Endopeptidases from Microbial Sources: Isolation of an Enzyme from a Xanthomonas sp".
Archives of Biochemistry and Biophysics, vol. 270, No. 1, pp. 255-266, 1989, Yamuna Dasarathy, et al., "A Peptidyl Dipeptidase-4 from Pseudomonas maltophilia: Purification and Properties".
Biochemical and Biophysical Research Communications, vol. 158, No. 1, pp. 45-51, Jan. 16, 1989, Joseph J. Lanzillo, et al., "Amino Acid Residues Essential for Catalysis by Peptidyl Dipeptidase-4 from Pseudomonas maltophilia".
International Journal of Systematic Bacteriology, vol. 33, No. 2, pp. 409-413, Apr. 1983, J. Swings, et al., "Transfer of Pseudomonas maltophilia Hugh 1981 to the Genus Xanthomonas as Xanthomonas maltophilia (Hugh 1981) Comb. Nov".
Bioscience Biotechnology and Biochemistry, vol. 59, No. 11, pp. 2087-2090, Koushirou Suga, et al., "Prolidase from Xanthomonas maltophilia: Purification and Characterization of the Enzyme".
Kabashima et al. (1996) J. Biochem., 120(6), "Dipeptidyl Peptidase IV from Xanthomonas maltophilia: Sequencing and Expression of the Enzyme Gene and Characterization of the Expressed Enzyme", pp. 1111-1117.
T. Yoshimoto et al. J. Biochem. vol. 91, No. 6, 1982; pp. 1899-1906, "Proline-Specific Dipeptidyl Aminopeptidase from Flavobacterium meningosepticum.sup.1 ".
K. Fukasawa et al. Archives Of Biochemistry and Biophysics, vol. 210, No. 1, Aug. 1981; pp. 230-237. "Purification and Properties of Dipeptidyl Peptidase IV from Streptococcus mitis ATCC 9811".

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