Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-04-11
2006-04-11
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S326000, C514S365000, C514S397000, C514S423000, C546S209000, C546S269700, C546S270400, C548S181000, C548S200000, C548S314700, C548S540000
Reexamination Certificate
active
07026316
ABSTRACT:
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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Golub et al., Science, Vol. 286, Oct. 15, 1999, pp. 531-537.
Ashworth, D. M., et al., “2-Cyanopyrrolidides As Potent, Stable Inhibitors Of Dipeptidyl Peptidase IV”, Bioorganic & Medicinal Chemistry Letters, Vol. 6, No. 10, pp. 1163-1166 (1996).
Ashworth, D. M., et al., “4-Cyanothiazolidides As Very Potent, Stable Inhibitors of Dipeptidyl Peptidase IV”, Biorganic & Medicinal Chemistry Letters, Vol. 6, No. 22, pp. 2745-2748 (1996).
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Ashton Wallace T.
Caldwell Charles G.
Ok Hyun O.
Parmee Emma R.
Weber Ann E.
Durette Philippe L.
Merck & Co. , Inc.
Stockton Laura L.
Winokur Melvin
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