Dipeptidyl peptidase I crystal structure and its uses

Details Dipeptidyl peptidase I crystal structure and its uses Dipeptidyl peptidase I crystal structure and its uses

2001-09-06

2010-06-15

Noakes, Suzanne M. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S195000, C435S212000, C435S219000, C435S226000

Reexamination Certificate

active

07736875

ABSTRACT:
The present invention relates to structural studies of dipeptidyl peptidase I (DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co-complexes. Included in the present invention is a crystal of a dipeptidyl peptidase I (DPPI) and corresponding structural information obtained by X-ray crystallography from rat and human DPPI. In addition, this invention relates to methods for using structure co-ordinates of DDPI, mutants hereof and co-complexes, to design compounds that bind to the active site or accessory binding sites of DPPI and to design improved inhibitors of DPPI or homologues of the enzyme.

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