Dipeptides, their preparation and compositions containing them

Details Dipeptides, their preparation and compositions containing them Dipeptides, their preparation and compositions containing them

1980-06-27

1982-12-07

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

043627161

ABSTRACT:
Dipeptides of the formula: ##STR1## in which R-CO represents a fatty acid residue and the symbols R.sub.1, which are identical or different, represent hydroxyl, amino or alkoxy containing 1 to 4 carbon atoms, which is optionally substituted by phenyl or nitrophenyl, it being understood that the alanine is in the L form and the glutamic acid or derivative thereof is in the D form, and their salts are immunological adjuvants and immunostimulants. They may be made using methods known per se in peptide chemistry and may be incorporated in pharmaceutical compositions.

REFERENCES:
patent: 4311640 (1982-01-01), Kuroda et al.
Biochem--and Biophys. Res. Commun. 59, 1974, 1317-1325.
Biochemistry vol. 9, No. 4, 1970, 823-831.
Comptes Rendus Hebdomandaires des Scanies de l'academie.varies.des Sciences Paris, pp. 1320-1304 (1965).
Bulletin de la Societe de Chimie Biologigie 1967, 49, No. 11, pp. 1579-1591.
Agricultural and Biological Chemistry 41, (5) 763-768, 1977.
11th Internat'l Congress of Chemotherapy-19th Interscience Conference on Antimicrobial Agents & Chemotherapy (1979).
Life Sciences 26, 883-888 (1980) "A Shor Lipopeptide, Representative of a New Family of Immunological Adjuvants Devoid of Sugar".
Comptes Rendus de l'Academie des Sciences (Paris), Series D 389, 437-476 (1979) "Properties Immunostimulantes et Adjuvantes d 'un Lipopeptide de Faible Poids Moleculares".

Affiliated with

Also associated with

Rating

Dipeptides, their preparation and compositions containing them does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dipeptides, their preparation and compositions containing them, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dipeptides, their preparation and compositions containing them will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1902995