Dipeptides as renin inhibitors

Details Dipeptides as renin inhibitors Dipeptides as renin inhibitors

1985-10-21

1989-09-05

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514397, 514400, 530331, 548336, 548344, A61K 3764

Patent

active

048639044

ABSTRACT:
Dipeptides are described which are represented by the formula ##STR1## wherein the various substituents are defined hereinbelow. These compounds have a strong inhibitory efect on human renin, and are useful as a therapeutically active agent for the treatment of hypertension, especially renin-associated hypertension.

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Matsueda et al., "Short Chain Peptide Inhibitors of Human Renin", Chemistry Letters, Chem. Soc., Japan, No. 7, pp. 1041-1044 (1985).
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Brown et al, "Protection of Histidine Side-Chains, etc.", Chemical Abstracts 95: 220299f (1981).
Colombo et al., "Acid-Labile Histidine Side-Chain Protection," Chemical Abstracts 101: 23914n (1984).
Kobuku et al., "Highly Potent and Specific Inhibitors, etc.," Biochemical and Biophysical Research Comm., vol. 118, No. 3, pp. 929-933 (2-1984).

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