Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1978-09-29
1980-05-27
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
042050693
ABSTRACT:
Novel dipeptides of the formula: A--X--Y--B wherein X is D-Tyr or L-Tyr; Y is D-Ala, L-Ala, D-Ser, L-Ser, or Gly; with the proviso that at least one of X and Y is of the D- configuration; A is hydrogen, allyl, or lower alkyl of 1 to 3 carbon atoms; B is --NH.sub.2, --OMe, or --NHNH.sub.2 ; and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions containing them, and a process for antagonizing the effects of a narcotic analgesic agent in warm blooded animals are disclosed.
REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
Pert et al., Nature 269, 73-75 (1977).
Janowsky et al., The Lancet, Aug. 5, 1978, pp. 320.
Beluzzi James D.
McGregor William H.
Stein Larry
American Home Products Corporation
Phillips Delbert R.
Wiser Robert
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