Dipeptide inhibitors of β-secretase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S331000, C530S332000, C562S553000

Reexamination Certificate

active

11075232

ABSTRACT:
Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.

REFERENCES:
patent: 4397786 (1983-08-01), Evans et al.
patent: 4522811 (1985-06-01), Eppstein et al.
U.S. Appl. No. 60/139,173, filed Jun. 15, 1999.
LePage R. N. (FEBS Letters 377(2), 267-70, 1995).
Lesne, Sylvain (Journal of Neuroscience 25(41), 9367-9377, 2005).
J. Med. Chem., 1993, 31, 2485.
Jones, D.M., J. Peptide Res., 1997, 50, 109-121.
Arrowsmith, R.J., J. Chem. Soc., Chem. Commun., 1986, 755-757.
Thaisrivongs, S., J. Med. Chem., 1987, 30, 1837-1842.
Rich, D.H., J. Med. Chem. 28, p. 262 (1985).
Merck Index (11thed.) at monograph No. 8759.

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