Dipeptide inhibitors of β-secretase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C562S553000, C530S331000, C530S332000

Reexamination Certificate

active

06864240

ABSTRACT:
Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatment by administration of these inhibitors to reduce Aβ peptide formation and in pharmaceutical compositions.

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Majer, Pavel, et al., “Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors”Protein Science, 6:1458-1466 (1977).

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