Dipeptide derivatives having an enzyme inhibitory action

Details Dipeptide derivatives having an enzyme inhibitory action Dipeptide derivatives having an enzyme inhibitory action

1992-01-28

1993-06-01

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514318, 530330, 530331, 546194, 2609982, C07K 506, A61K 3702, C07D24104, C07D27742

Patent

active

052159680

ABSTRACT:
Dipeptide derivatives having an enzyme inhibitory action Compounds of the formula I ##STR1## in which R.sup.1 represents a (substituted) heterocyclyl-alkyl, -alkoxy, -cycloalkyl or -cycloalkoxy and the corresponding heterocyclylmercapto radicals, A and B independently of one another denote an amino acid, R.sup.2 is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, aryl or aryl-alkyl, R.sup.3 represents hydrogen, alkyl, aryl, aryl-alkyl or hydroxyl and R.sup.4 denotes a radical (CH.sub.2).sub.0-4 CHR.sup.5 -D where R.sup.5 =hydrogen, alkyl, alkoxy, alkylthio, alkylamino, hydroxyl, azido or halogen and D=(substituted) heterocyclyl, have enzyme-inhibiting properties. Processes for the preparation of compounds of the formula I and their use in the treatment of hypertension and viral diseases are described.

REFERENCES:
Haber et al., J. Cardiovasc. Pharmacol., 1987, 10 (Supp. 7), pp. 554-558.
Burger, Medicinal Chemistry, Second Edition, Jun. 27, 1960, Interscience Publishers, Inc. New York, N.Y., pp. 565-571, 578-581, 600-601.
Bolis et al., J. Med. Chem., 1987, 30(10), pp. 1729.sub.]1737.
Plattner et al., J. Med. Chem., 1988, 31(12), pp. 2277-2288.
Denkewalter et al., Progress in Drug Research, 1966, vol. 10, pp. 510-512.

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