Dipeptide derivatives and antihypertensive drugs containing them

Details Dipeptide derivatives and antihypertensive drugs containing them Dipeptide derivatives and antihypertensive drugs containing them

1988-09-01

1990-11-20

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514423, 548518, 548533, 548537, A61K 3140

Patent

active

049719939

ABSTRACT:
There are disclosed dipeptide derivatives represented by the general formula: ##STR1## wherein R.sup.1 is a radical selected from the group consisting of alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.2 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.3 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, R.sup.4 is a radical selected from the group consisting of hydrogen atoms and alkyl, aralkyl and aryl groups optionally containing one or more substituent groups, and R.sup.5 is a radical selected from the group consisting of hydroxyl, amino, hydroxyamino, alkyloxy, aralkyloxy, aryloxy, alkylamino, aralkylamino, arylamino, alkyloxyamino, aralkyloxyamino, aryloxyamino, acylamino and sulfonylamino groups, which alkyloxy, aralkyloxy and aryloxy groups optionally containing one or more substituent groups; wherein R.sup.3 may be combined with R.sup.2 or R.sup.4 to form an alkylene bridge optionally containing one or more oxygen atoms, sulfur atoms and nitrogen atoms and optionally containing one or more substituent groups. However, certain dipeptide derivatives within the above general formula are excluded from the invention. The dipeptide derivatives are useful for the treatment of hypertension.

REFERENCES:
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patent: 4642355 (1987-02-01), Nakamura et al.
patent: 4670420 (1987-06-01), Okamoto et al.
Beecham, J.A.C.S., 79, (1957), pp. 3257-3261.
Beecham, J.A.C.S., 79, (1957), pp. 3262-3263.

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