Dipeptide derivative of fatty acid

Details Dipeptide derivative of fatty acid Dipeptide derivative of fatty acid

1986-04-16

1988-09-20

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514359, 514408, 514423, 530323, 530331, 530332, A61K 3702, C07D20700

Patent

active

047725877

ABSTRACT:
A novel compound that exhibits inhibitory activity against prolyl endopeptidase and a method for chemical synthesis of said compound, as well as its use as a prolyl endopeptidase inhibitor and an anti-amnesic agent that contains said compound as the active ingredient are provided.

REFERENCES:
The Proceedings of 1984 Annual Meeting, pp. 752-754.
Nakamura et al, "The Monomolecular Films of U-Palmitoyl-L-Proline Oligomers" J. of Coll. and Interface Science, vol. 61, No. 1, 1977, pp. 86-94.
"Inhibition of Rabbit Brain Prolyl Endopeptidase by N-Benzyloxy-Carbonyl-Prolyl-Prolinal, A Transition State Aldehyde Inhibitor", Journal of Neurochemistry, vol. 41, No. 1, 1983, pp. 69-75.

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