Dipeptide compounds containing histidine or N-methyl histidine p

Details Dipeptide compounds containing histidine or N-methyl histidine p Dipeptide compounds containing histidine or N-methyl histidine p

1988-12-06

1991-10-15

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

546194, 546278, A61K 3702, C07K 506

Patent

active

050574965

ABSTRACT:
There are described new compounds of formula (1) ##STR1## wherein R.sup.1 represents an acyl group;

REFERENCES:
patent: 4533656 (1985-08-01), Walker
patent: 4548926 (1985-10-01), Matsueda et al.
patent: 4616088 (1986-10-01), Ryono et al.
patent: 4665193 (1987-05-01), Ryono et al.
patent: 4705846 (1987-11-01), Thaisrivongs
patent: 4719288 (1988-01-01), Fuhrer et al.
patent: 4746649 (1988-05-01), Raddatz et al.
patent: 4749687 (1988-06-01), Bindra et al.
Burger, Medicinal Chemistry, 2nd Edition, Interscience Publishers, Inc., N.Y., pp. 565-601 (6/27/60).
Bolis et al., Renin Inhibitors Dipeptide Analogues of Angiotensinogen Incorporating Transition-State, Nonpeptidic Replacements at the Scissile Bond, J. Med. Chem., pp. 1729-1739, vol. 30, (1987).
Haber et al., Renin Inhibitors: A Search for Principles of Design, J. Cardiovascular Pharmacology, 10 (Supplement 7) pp. 554-558, (1987).

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