Dipeptide caspase inhibitors and the use thereof

Details Dipeptide caspase inhibitors and the use thereof Dipeptide caspase inhibitors and the use thereof

1999-03-16

2000-11-28

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 11, 435 12, 435 2, 548200, 549 76, 549 77, 549493, 549494, 560 37, 560 38, 560 39, 560 40, 560 41, 560 42, 560125, 560169, 562442, 562443, 562444, 562445, 562448, 562449, A01N 102, A01N 300, A61K 3805, C07K 506

Patent

active

061535915

ABSTRACT:
The present invention is directed to novel dipeptides represented by the general Formula I: ##STR1## where R.sub.1 -R.sub.2 and AA are defined herein. The present invention relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.

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