Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-10-20
1995-10-31
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514422, 514414, 514387, 514375, 514343, 514314, 514213, 514183, 548405, 548413, 548110, 546 15, 540452, 540485, 540487, A61K 3140, C07D20704
Patent
active
054629640
ABSTRACT:
The present invention relates to the discovery of new C-terminal boronic acid dipeptide inhibitors of trypsin-like enzymes such as thrombin and pharmaceutical compositions thereof.
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patent: 5232920 (1993-08-01), Neustadt
patent: 5288707 (1994-02-01), Metternich
Balasubramanian, et al. J. Med. Chem. 36, 300 (1993), Active Site-Directed . . . Series.
Abelman Matthew M.
Amparo Eugene C.
Cacciola Joseph
Fevig John M.
Kettner Charles A.
McKane Joseph K.
The Du Pont Merck Pharmaceutical Company
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