Dipeptide alkyl esters and their uses

Details Dipeptide alkyl esters and their uses Dipeptide alkyl esters and their uses

1985-09-09

1988-06-21

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3702

Patent

active

047526025

ABSTRACT:
An alkyl ester of dipeptide consisting essentially of natural or synthetic L-amino acids with hydrophobic side chains. Preferable amino acids are leucine, phenylalanine valine, isoleucine, alanine, proline, glycine or aspartic acid beta methyl ester. Preferable dipeptides are L leucyl L-leucine, L-leucyl L-phenylalanine, L-valyl L-phenylalanine, L-leucyl L-isoleucine, L-phenylalanyl L-phenylalanine, L-valyl L-leucine, L-leucyl L-alanine, L-valyl L-valine, L-phenylalanyl L leucine, L prolyl L-leucine, L-leucyl L-valine, L-phenylalanyl L-valine, L glycyl L-leucine, L-leucyl L-glycine or L-aspartyl beta methyl ester L-phenylalanine. Most preferable dipeptides are L-leucyl L-leucine, L-leucyl L-phenylalanine, L-valyl L-phenylalanine, L-phenylalanyl L-leucine, L-leucyl L-isoleucine L-phenylalanyl L-phenylalanine and L-valyl L-leucine.
The alkyl ester of the dipeptide is most preferably a methyl ester and may also be an ethyl ester or alkyl of up to about four carbon atoms such as propyl, isopropyl, butyl or isobutyl.
These alkyl esters of dipeptides consisting essentially of amino acids with hydrophobic side chains may be used to deplete cytotoxic T-lymphocytes or natural killer cells from organisms, cell populations or tissues.

REFERENCES:
patent: 4555502 (1985-11-01), Patchett et al.
patent: 4585757 (1986-04-01), Pang et al.
patent: 4616012 (1986-10-01), Neustadt et al.
Goldman (1973), FEBS Letters, 33, 208.
Reeves (1979), J. Biol. Chem., 254, 8914.
Thiele et al. (1983), J. Immunol., 138, 51.
Verhoef et al. (1983), J. Immunol., 131, 125.
Shau et al. (1985), J. Immunol., 134, 718.
Trinchieri et al. (1978), J. Exp. Med., 147, 1314.
Charley et al. (1986), J. Clin. Invest., 78, 1415.
Thiele et al. (1987), J. Immunol., 138, 51.
Gidlund et al. (1978), Nature, 273, 51.
Lopez et al. (1979), Lancet, Nov. 24, 1103.
Seeley et al. (1979), J. Immunol., 123, 1303.
Roder et al. (1979), J. Immunol., 123, 2785.
Kendall et al. (1980), J. Immunol., 125, 2770.
Lopez et al. (1980), Lancet, Nov. 5, 1025.
Breard et al. (1980), J. Immunol., 124, 1943.
Zarling et al. (1981), J. Immunol., 127, 2575.
Ortaldo et al. (1981), J. Immunol., 127, 2401.
Timonen et al. (1981), J. Exp. Med., 153, 569.
Reeves et al. (1981), Proc. Nat'l. Acad. Sci. USA, 78, 4426.
Herberman et al. (1981), Science, 214, 24.
Dokhelar et al. (1981), Transplantation, 31, 61.
Grimm et al. (1982), J. Expt'l. Med., 155, 1823.
Warner et al. (1982), Nature, 300, 31.
Hiserodt et al. (1982), J. Immunol., 129, 2266.
Quan et al. (1982), J. Immunol., 128, 1786.
Seaman et al. (1982), J. Clin. Invest., 69, 876.
Dempsey et al. (1982), J. Immunol., 129, 2504.
Koren et al. (1982), Molec. Immunol., 10, 1341.
Katz et al. (1982), J. Immunol., 129, 287.
Hiserodt et al. (1982II), J. Immunol., 129, 1782.
Bonavida et al. (1983), Immunolog. Rev., 72, 119.
Podack et al. (1983), Nature, 302, 442.
Dennert et al. (1983), J. Exp. Med., 157, 1483.
Burns et al. (1983), Proc. Nat'l. Acad. Sci. USA, 80, 7606.
Hattori et al. (1983), J. Immunol., 131, 662.
Perussia, et al. (1983), J. Immunol., 130, 2133.
Seaman (1983), J. Immunol., 131, 2953.
Domzig et al. (1983), J. Immunol., 130, 1970.
Komiyama et al. (1984), Cancer, 54, 1547.
Kleinerman et al. (1984), J. Immunol., 133, 4.
Vadas et al. (1984), J. Immunol., 133, 202.
Calvo et al. (1984), J. Immunol., 132, 2345.
Holmberg et al. (1984), J. Immunol., 133, 2933.
Trinchieri et al. (1984), Lab. Invest., 50, 489.
London et al. (1985), Immunol., 134, 718.

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