Dioxy hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline deriva

Details Dioxy hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline deriva Dioxy hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline deriva

1983-06-13

1985-06-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 75, A61K 31435, C07D22118

Patent

active

045229465

ABSTRACT:
1,2,3,7,8,12b-Hexahydrobenzo[6,7]cyclohepta[1,2,3-de]isoquinoline derivatives, characterized by having two adjacent oxy substituents at positions 4 and 5 or at positions 5 and 6, are disclosed. Thus, the substituent at position 5 is lower alkoxy or hydroxy and the substituents at positions 4 and 6 are different and are hydrogen or hydroxy. The derivatives are neuroleptic agents, free of extrapyramidal side effects. Methods for the preparation and for the use of the derivatives also are disclosed.

REFERENCES:
patent: 3403157 (1968-09-01), Humber et al.
L. G. Humber et al., J. Heterocycl. Chem., 3, 247, (1966).
L. G. Humber et al., Can. J. Chem., 46, 2981, (1968).

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