Dioxolobenzizoxazole derivatives

Details Dioxolobenzizoxazole derivatives Dioxolobenzizoxazole derivatives

1986-03-18

1988-03-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548242, C07D26120

Patent

active

047329068

ABSTRACT:
Dioxolobenzisoxazole derivatives of the formula ##STR1## wherein R.sub.1 is a phenyl group which may be substituted with a halogen atom, a lower alkyl group having 1-3 carbon atoms or a lower haloalkyl group, or a thienyl group; R.sub.2 is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; and X and Y which may be the same or different represent a hydrogen atom or a halogen atom, as well as non-toxic salts thereof wherein R.sub.2 is a hydrogen atom, a process for preparing the same and a pharmaceutical composition containing the same are disclosed.
The derivatives have diuretic and uricosuric activities and, therefore, are useful as a drug for treating hyperuricemia or hypertension.

REFERENCES:
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patent: 4456612 (1984-06-01), Plattner et al.
patent: 4560558 (1985-12-01), Parks et al.
Shutske et al, "[(3-Aryl-1,2-benzisoxasol-6-yl)oxy ]acetic Acids, A New Diuretic Series", J. Med. Chem. vol. 25, 1982, pp. 36-44.
Plattner et al, "Substituted 5,6-Dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic Acids; High-Ceiling Diuretics with Uricosuric Activity", J. Med. Chem., vol 27, 1984, pp. 1016-1026.

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