Dioxolane derivatives

Details Dioxolane derivatives Dioxolane derivatives

1981-03-11

1982-09-07

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562469, 568428, C07D31734

Patent

active

043483224

ABSTRACT:
The invention is concerned with novel dioxolane derivatives of the formula: ##STR1## in which R.sub.a is hydrogen or (1-4C)alkyl and R.sub.b is (1-4C)alkyl or phenyl optionally bearing a halogeno substituent; their production; and their use for the manufacture of certain known anti-arthritic acids of the formula: ##STR2## and, in particular, those acids in which R.sub.a =R.sub.b =methyl or R.sub.a =ethyl and R.sub.b =phenyl, by a novel reduction process. The preferred reduction procedures involve the use of an alkali metal borohydride or cyanoborohydride in the presence of a noble metal catalyst, or the use of an .alpha.-branched alkyl or cycloalkyl Grignard agent.
The use of the derivatives of formula I avoids the need for potentially toxic reagents and reactive intermediates in the previously known processes for the production of the acids of formula V.

REFERENCES:
patent: 3299127 (1967-01-01), Zienty
patent: 3303202 (1967-02-01), Gallo et al.
J. American Chem. Soc., 1942, 64, 1567-1571, 1955, 77, 3131-3132, Fuson and Rachlin.

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