Dioxobutanoic acid derivatives as inhibitors of influenza endonu

Details Dioxobutanoic acid derivatives as inhibitors of influenza endonu Dioxobutanoic acid derivatives as inhibitors of influenza endonu

1994-10-17

1995-12-12

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546153, 546157, 546168, 546172, 546193, 546197, 546199, 546205, 546207, 546212, 546214, 544311, 544312, 540480, 540481, 540482, 540597, 540598, 540610, C07D21132, C07D40106

Patent

active

054751098

ABSTRACT:
Dioxobutanoic acids substituted with piperidine or similar N-substituted saturated cycloalkyls are found to inhibit the cap-dependent endonuclease of influenza virus. These compounds are useful in the prevention or treatment of infection by influenza virus and the treatment of influenza, either as compound, pharmaceutically acceptable salts,. pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating influenza and methods of preventing or treating infection by influenza virus are also described.

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Grell et al. "Syntheses with organophosphorus compounds I Ester olfeination" CA 65:7210-7212.
Pinto, et al., "Influenza Virus M2 Protein Has Ion Channel Activity", Cell., vol. 69, pp. 517-528, May 1, 1992.
Williams, et al., "Inhibitors of Glycolic Acid Oxidase. 4-Substituted 2,4-Dioxabutanoic Acid Derivatives", J. Med. Chem., vol. 26, pp. 1196-1120, 1983.

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