Dioxo-tetrahydroquinoline derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514253, 5142352, 514266, 544128, 544238, 544336, 544405, 544 90, 546139, 546156, 546155, C07D21558

Patent

active

052683788

ABSTRACT:
A class of 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a five- or six-membered heteroaromatic moiety, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.

REFERENCES:
patent: 3574216 (1971-08-01), Bell
patent: 5175151 (1992-12-01), Afonso et al.
patent: 5179003 (1983-01-01), Afonso et al.
patent: 5179107 (1993-01-01), Afonso et al.

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