Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-01-22
1993-12-07
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514253, 5142352, 514266, 544128, 544238, 544336, 544405, 544 90, 546139, 546156, 546155, C07D21558
Patent
active
052683788
ABSTRACT:
A class of 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a five- or six-membered heteroaromatic moiety, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.
REFERENCES:
patent: 3574216 (1971-08-01), Bell
patent: 5175151 (1992-12-01), Afonso et al.
patent: 5179003 (1983-01-01), Afonso et al.
patent: 5179107 (1993-01-01), Afonso et al.
Baker Raymond
Leeson Paul D.
Rowley Michael
Sevenson Graeme I.
Daus Donald G.
DiPrima Joseph F.
Merck Sharp & Dohme Limited
Nicholson William H.
North Robert J.
LandOfFree
Dioxo-tetrahydroquinoline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Dioxo-tetrahydroquinoline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dioxo-tetrahydroquinoline derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2015969