Dioximino cephalosporin antibiotics

Details Dioximino cephalosporin antibiotics Dioximino cephalosporin antibiotics

1983-06-03

1984-05-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 25, 544 21, 424246, C07D50138, A61K 31545

Patent

active

044502702

ABSTRACT:
Broad spectrum cephalosporin betaine antibiotics represented by the formula ##STR1## wherein Q is an oximino-substituted pyridinium, quinolinium or isoquinolinium group of the formulas ##STR2## wherein R.sub.1 and R.sub.2 are hydrogen or C.sub.1 -C.sub.3 alkyl; and R' is an amino-substituted 5- or 6-membered heterocyclic, e.g., 2-aminothiazol-4-yl; and R" is C.sub.1 -C.sub.4 alkyl, an N-substituted carbamoyl group, or a carboxy-substituted alkyl or cycloalkyl group; have potent activity vs. G.sup.- organisms. Pharmaceutical formulations and a method for treating infectious disease with above compounds are provided.

REFERENCES:
patent: 4200575 (1980-04-01), Numata et al.
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4267176 (1981-05-01), Kamiya et al.
patent: 4278671 (1981-07-01), Ochiai et al.
patent: 4336253 (1982-06-01), Lunn et al.
patent: 4402955 (1983-09-01), Lunn
Derwent Abstract 32890, 0/19.
Nomura et al., Jour. of Med. Chem. vol. 17, No. 12, pp. 1312-1315 (1974).

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