Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-04-16
1984-07-31
Raymond, Richard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603308, 42424851, 42424853, 42424854, 42424855, 42424856, 42424857, 544105, A61K 31535, C07D49108
Patent
active
044630042
ABSTRACT:
Compounds having analgesic activity are disclosed which have the general formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl having 1 to 4 carbon atoms, cyclohexyl or benzyl; R is selected from the group consisting of alkyl having at least 4 carbon atoms; cyclohexyl; unsubstituted phenyl or phenyl substituted with one or more halogen atoms, methyl, methoxy, hydroxy, cyano, nitro, trifluoromethyl, carboxyl, ethoxycarbonyl, acetamido, methylsulfonyl, phenoxy, benzoyl, phenyl, .alpha.-hydroxybenzyl, cyclohexyl or carbamoyl; thienyl; pyridyl; naphthyl; naphthyl substituted with methoxy; adamantyl; and benzyl; and n is 1, 2 or 3, with the provisos that (1) when R is carboxyphenyl, benzoylphenyl, or (.alpha.-hydroxybenzyl) phenyl, n is not 3, and (2) when R is (.alpha.-hydroxy benzyl) phenyl, R.sub.1 is not benzyl, and acid addition salts thereof.
REFERENCES:
The Ring Index, Second Edition, Chemical Abstracts Service, (1960), p. 161.
May et al., Chemical Abstracts, vol. 68, (1968), 85834b.
May et al., "Cholinergic Receptor I. Cholinomimetic Activities of Some Analogs of cis-2-Methyl-4-dimethylaminomethyl-1,3-dioxolane Methiodide", Journal of Pharmaceutical Sciences, vol. 57, No. 3, Mar. 1968, pp. 511-513.
Vogel et al., "Protective Effects of Dimethyl-Propranolol (UM-272) During Global Ischemia of Isolated Feline Hearts", J. Pharm. Exp. Therap., vol. 212, 1980, pp. 560-568.
Gibson et al., "Electrophysiologic Effects of UM-272 on Myocardial Ischemia in the Canine Heart", J. Pharm. Exp. Therap., vol. 207, 1978, pp. 304-310.
Bucher Bernard P.
Dostert Philippe L.
Guerret Patrick G.
Mocquet Gisele C.
Nedelec Alain L.
Delalande S.A.
Raymond Richard
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