Dioxapyrrolomycin as an antiparasitic agent and compositions use

Details Dioxapyrrolomycin as an antiparasitic agent and compositions use Dioxapyrrolomycin as an antiparasitic agent and compositions use

1995-05-01

1997-07-01

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3140

Patent

active

056439407

ABSTRACT:
This invention concerns a method for killing internal parasites, especially nematodes, trematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effective amount of dioxapyrrolomycin of the formula I. Anthelmintic compositions of dioxapyrrolomycin and an improvement in the process of preparation of dioxapyrrolomycin are also provided. ##STR1##

REFERENCES:
patent: 4495358 (1985-01-01), Koyama et al.
The Journal of Antibiotics, vol. XXXIV No. 10, "New Chlorinated Nitro-Pyrrole Antibiotics, Pyrrolomycin A and B (SF-2080 A and B)", N. Ezaki, et al., pp. 1363-1365, (1981).
The Journal of Antibiotics, vol. XXXIV No. 10, "Structure of Pyrrolomycin B, A Chlorinated Nitro-Pyrrole Antibiotic", M. Kaneda, et al., pp. 1366-1368, (1981).
The Journal of Antibiotics, vol. XXXIV No. 12, "Structure and Synthesis of Pyrrolomycin A. A Chlorinated Nitro-pyrrole Antibiotic", M. Koyama, et al., pp. 1569-1576, (1981).
The Journal of Antibiotics, vol. XXXVII No. 10, "Enhancement of Mouse Immune System by Pyrrolomycin B", M. Ishizuka, et al., pp. 1253-1256, (1984).
The Journal of Antibiotics, vol. XL No. 2, "LL-F42248.alpha., A Novel Chlorinated Pyrrole Antibiotic", GT Carter, et al., pp. 233-236, (1987).
The Journal of Antibiotics, vol. XL No. 6, "Isolation and Characterization of a New Antibiotic, Dioxapyrrolomycin, Related to Pyrrolomycins", Hikaru Nakamura, et al., pp. 899-903, (1987).
ACS Meeting Abstracts 97, 98, 99 Spring 1991, Addar et al.
J. Chem. Soc. Chem. Commun., "Direct Biochemical Nitration in the Biosynthesis of Dioxapyrrolomycin. A Unique Mechanism for the Introduction of Nitro Groups in Microbial Products", GT Carter, et al., pp. 1271-1273, (1989).
K. Masuda, et al., "Pyrrolomycin Group Antibiotics Inhibit Substance P-Induced Release of Myeloperoxidase From Human Polymorphonuclear Leukocytes", The Journal of Antibiotics, vol. 44, No. 5, pp. 533-540 (1991).
K. G. Simpkin et al., "The Use of Caenorhabditis Elegans for Anthelmintic Screening", Journal of Chemical Technology and Biotechnology, vol. 31, pp. 66-69 (1981).
K. Yano et al., "Pyrroxamycin, a New Antibiotic Taxonomy, Fermentation, Isolation, Structure Determination and Biological Properties", vol. KL, No. 7, pp. 961-969 (1987).
S. Rengaraju et al., "A New Antibiotic Al-R 2081 Related to Pyrrolomycin B", Meiji Seika Kenkyu Nenpo, India, vol. 24, pp. 48-51, (1985).
V.P. Marshall et al., "Current Fermentation Technology for the Production of Antibiotics from Actinomycetes: The Example of Paulomycin", Developments in Industrial Microbiology (Journal of Industrial Microbiology Suppl. No. 2). vol. 28, pp. 105-114 (1987).

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