Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-11-08
1985-02-19
Love, Ethel G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544153, 546270, 548530, 549433, 260239B, 514338, A61K 3136, A61K 3144, C07D40100, C07D31770
Patent
active
045005427
ABSTRACT:
The invention relates to novel dioxaheterocyclic compounds of the formula I ##STR1## in which R.sub.1 represents an unsubstituted or substituted aromatic or heteroaromatic radical or an unsubstituted or lower alkylated, mono- or bi-cyclic cycloaliphatic hydrocarbon radical or an .alpha.-branched aliphatic hydrocarbon radical, each of R.sub.2 and R.sub.3, independently of the other, represents hydrogen or lower alkyl, and each of R.sub.4 and R.sub.5, independently of the other, represents hydrogen, lower alkyl or halogen, and A represents the radical --O--R.sub.6, wherein R.sub.6 represents hydrogen or an unsubstituted or substituted aliphatic or araliphatic hydrocarbon radical or A represents the radical ##STR2## in which each of R.sub.7 and R.sub.8, independently of the other, represents hydrogen or lower alkyl, or R.sub.7 and R.sub.8 are bonded to one another and, together with the adjacent nitrogen atom, represent unsubstituted or lower alkyl-substituted tetra- to hexa-methyleneimino or 4-morpholinyl, and the divalent radical in formula I is either in the 4,5- or the 5,6-position and correspondingly R.sub.4 and R.sub.5 are in positions 6 and 7, or 4 and 7, respectively, of the benzodioxole skeleton, to salts of compounds of the formula I in which A represents OR.sub.6 wherein R.sub.6 represents hydrogen, with bases, as well as acid addition salts of compounds of the formula I in which the radical R.sub.1 is of basic character, and to pharmaceutical compositions containing them. These novel substances have a diuretic activity and, in addition, a uricosuric activity, and can be administered, according to the invention, preferably in the form of corresponding pharmaceutical compositions, to mammals for the treatment of oedema and hypertension.
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Chem. Abstracts, 71:30377m, (1969).
Chem. Abstracts, 69:18804z, (1968), 1967-71 Subject Index.
Habicht Ernst
Zbinden Paul
Ciba-Geigy Corporation
Feit Irving N.
Love Ethel G.
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