Diol sulfonamide and sulfinyl renin inhibitors

Details Diol sulfonamide and sulfinyl renin inhibitors Diol sulfonamide and sulfinyl renin inhibitors

1989-09-15

1992-03-24

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514398, 514400, 544139, 544238, 544370, 544406, 546278, 546338, 548215, 548327, 548336, 548337, 548342, 548344, 564 80, 564 93, A61K 31415, C07D23364, C07D40312

Patent

active

050989243

ABSTRACT:
Compounds of the formula ##STR1## wherein Z is SO or SO.sub.2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of circulating angiotensin II are beneficial.

REFERENCES:
patent: 4645759 (1987-02-01), Luly et al.
patent: 4657931 (1987-04-01), Baran et al.
patent: 4680284 (1987-07-01), Luly et al.
patent: 4725583 (1988-02-01), Luly et al.
patent: 4837204 (1989-06-01), Rosenberg et al.
patent: 4864017 (1989-09-01), Thaisrivongs
patent: 4904660 (1990-02-01), Nakano et al.

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