Diol sulfonamide and sulfinyl renin inhibitors

Details Diol sulfonamide and sulfinyl renin inhibitors Diol sulfonamide and sulfinyl renin inhibitors

1992-01-27

1996-08-13

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

546335, 544238, 544224, 544406, 5483335, 5483385, 548204, 548486, 548507, 564248, 564 84, 564 85, 564 86, 564 88, 564 95, C07D23364, C07D27730, C07D20934, C07D20910, C07D21182, C07D23700, C07D40300, C07C30900

Patent

active

055458386

ABSTRACT:
Compounds of the formula ##STR1## wherein Z is SO or SO.sub.2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of circulating angiotensin II are beneficial.

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Haber et al., J. Cardiovascular Pharmacology, 10 (Suppl. 7) 554-558 (1987).

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