Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-12-22
1989-09-12
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544263, A61K 31505, C07D48704
Patent
active
048660639
ABSTRACT:
1-(5-Amino-7-phenyl-[1,2,4] triazolo [1,5,c]pyrimidin-8-yl)-1, 2-ethan diol, a novel glycol of a triazolopyrimidine diuretic which is a metabolite and which exhibits fewer cardiotoxic side effects than the parent compound, but with no decrease in diuretic activity. The invention further provides for compositions incorporating the metabolite, and methods of its use as well as pharmaceutically acceptable salts thereof.
REFERENCES:
patent: 4405780 (1983-09-01), Wagner
patent: 4483987 (1984-11-01), Wagner
patent: 4652192 (1985-12-01), Wagner
"Diuretics: Chemistry, Pharmacology and Clinical Applications", ed. J. B. Puschett, (Elsevier, New York, N.Y.) 1988.
"Drugs of the Future", vol. 10, No. 4, pp. 298-300 (1985).
Burton Earl G.
Chengelis Christopher P.
Walsh Gerald M.
Daus Donald G.
G. D. Searle & Co.
Grassler Frank P.
Matukaitis Paul D.
LandOfFree
Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5- does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5- will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-916450