Diol-containing renin inhibitors

Details Diol-containing renin inhibitors Diol-containing renin inhibitors

1991-04-01

1993-11-09

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

5142378, 514399, 530860, 544159, 5483421, 5483425, A61K 3702, C07D26530, C07D29526, C07K 506

Patent

active

052602788

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.

REFERENCES:
patent: 5036054 (1991-07-01), Kaltenbronn et al.
patent: 5122514 (1992-06-01), Boger et al.
patent: 5122523 (1992-06-01), Morishima et al.
patent: 5178877 (1993-01-01), Garren et al.
Denkewalter et al., "Progress in Drug Research", vol. 10 pp. 510-512 (1966).
Burger, "Medicinal Chemistry", second edition, pp. 565-571, 578-581, 600-601 (1960).
Plattner et al., "Renin Inhibitors Dipeptide Analogues" J. Med. Chem. 1988, 31, 2277-2288.
Bolis et al., "Renin Inhibitors. Dipeptide Analogues" J. Med. Chem. 1987, 30, 1729-1737.
Haber et al., "Renin Inhibitors: A Search . . . " Journal of Card. Pharm. 10(Suppl. 7):554-558 (1987).

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