Dinucleotides useful for the treatment of cystic fibrosis and fo

Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid

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424 46, 514851, A61K 912

Patent

active

056351607

ABSTRACT:
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is disclosed: ##STR1## wherein: n is from 1 to 6;

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M. Knowles et al., Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis. N. Engl. J. Med. 325: 533-538 (1991).
M. Knowles et al., Extracellular ATP and UTP Induce Chloride Secretion in Nasal Epithelia of Cystic Fibrosis Patients and Normal Subjects in vivo. Chest 101:60S-63S (1992).
S. Mason et al.; Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium. Br. J. Pharmacol 103:1649-1656 (1991).
K. NG et al.; The action of a water-soluble carbodiimide on adenosine-5'-polyphosphates. Nucl. Acids Res. 15:3573-3580 (1987).
M. Stutts et al.; Multiple modes of regulation of airway epithelial chloride secretion by extracellular ATP. Am. J. Physiol. 267:C1442-1451 (1994).

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