Dinucleoside pyrophosphates and pyrophosphate homologs as plant

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 48, 514 51, 536 27, 536 28, 536 29, 47 58, A61K 3170, A61K 31665

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048553042

ABSTRACT:
Potent plant antivirals are disclosed along with their method of use. These antivirals, 5',5'- or 2',5'- or 3',5'-pyrophosphorylated-dinucleotides, are specifically shown to inhibit tobacco mosaic virus (TMV) replication in tobacco plants when applied to the leaves or through the roots of these plants. These antiviral compounds can also be used to treat a variety of other plants, as disclosed herein, which are susceptible to a broad range of viruses.

REFERENCES:
patent: 3321463 (1967-05-01), Moffatt
England et al., Proc. Nat. Acad. Sci., U.S.A. 74(11), 4839-4842, 1977.
Bartkiewicz et al., Chem. Abstr., 102, 185421d, 1984.
Stone, Chem. Abstr, 100, 34777g, 1984.
Ohtsuka et al., J. Chem. Soc., Perkin Trans I, 1985, 997-1000.
Bartkiewicz et al., Chem. Abstr., 102: 2366x, 1985.
Stone, Chem. Abstr., 98: 154915n, 1983.
Ohtsuka et al., Nucleic Acids Research, vol. 8, pp. 601-610, 1980.
Devash, Y., Hauschner, A., Sela, I. and Chakraburtty, K. (1981), "The Antiviral Factor (AVF) from Virus-Infected Plants Induces Discharge of Histidinyl-TMV-RNA Virology", 111: 103-112.
Devash, Y., Biggs, S. and Sela, I. (1982), "Multiplication of Tobacco Mosaic Virus in Tobacco Leaf Disks is Inhibited by (2'-5') Oligoadenylate"0. Science, 216: 1415-1416.
Devash, Y. et al. (1984), "5'-Dephosphorylated 2',5'-Adenylate Trimer and Its Analogs", Journ. Biol. Chem. 259: 3482-3486.
Lee, C., and R. J. Suhadolnik (1985), "2',5'-Oligoadenylates Chiral at Phosphorus: Enzymatic Synthesis, Properties, and Biological Activities of 2',5'-Phosphorothioate Trimer and Tetramer Analogs Synthesized from (Sp)-ATP.alpha.S", Biochem. 24:3: 551-555.
Eckstein, F., P. H. Romaniuk, and B. A. Connolly (1982), "Stereochemistry of Enzymatic Phosphoryl and Nucleotidyl Transfer", Methods of Enzymology, 87: 197-212.
Knowles, J. R. (1980), "Enzyme Catalyzed Phosphoryl Transfer Reactions", Ann. Rev. Biochem., 1980, 49: 877-919.
Frey, P. A., J. P. Richard, H.-T. Ho, R. S. Brody, R. D. Sammons, and K.-F. Sheu (1982), "Stereochemistry of Selected Phosphotransferases and Nucleotidyltransferases", Methods in Enzymology, 87: 213-235.
Wood, R. K. S. (ed.), Active Defense Mechanisms in Plants, Plenum Press, New York and London.
Dawson, W. O. (1984), "Effects of Animal Antiviral Chemicals on Plant Viruses", Phytopathology, 74: 2: 211-213.
Kluge, S., and C. Oertel (1976), "Prufung von Virazol auf die Vermehrung des Gurkenmosaik-Virus (cucumber mosaic virus) und des Nelkenscheckungs-Virus (carnation mottle virus)", Arch. Phytopathol. u. Pflanzenschutz, 4: 219-225.
Mitteilung, J. (1979), "Dioxohexahydrotriazin, Eine Neue Vollsynthetische Antiphytovirale Verbindung", Zbl. Bakt. II. Abt. 134: 64-69.
Kassanis, B., and R. F. White (1975), "Polyacrylic Acid-Induced Resistance to Tobacco Mosaic Virus in Tobacco cv. Xanthi", Ann. Appl. Biol., 79: 215-220.
Stein, A., and G. Loebenstein (1972), "Induced Interference by Synthetic Polanions with the Infection of Tobacco Mosaic Virus", Phytopathology 62: 1461-1466.
Stein, A., G. Loebenstein and S. Spiegel (1979), "Further Studies of Induced Interference by a Synthetic Polyanion of Infection by Tobacco Mosaic Virus", Physiological Plant Pathology, 15: 241-255.
Smookler, M. M. (1971), "Properties of Inhibitors of Plant Virus Infection Occurring in the Leaces of Species in the Chenopodiales", Ann. Appl. Biol., 69: 157-168.
Tomlinson, J. A., V. M. Walker, T. H. Flewett and G. R. Barclay (1974), "The Inhibition of Infection by Cucumber Mosiac Virus and Influenza Virus by Extracts from Phytolacca americana", J. Gen. Virol., 22: 225-232.
Bartkiewicz, M., H. Sierakowska, and D. Shugar (1984), "Nucleotide Pyrophosphatase from Potato Tubers", Eur. J. Biochem., 143: 419-426.

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