Dinucleoside poly(borano)phosphate derivatives and uses thereof

Details Dinucleoside poly(borano)phosphate derivatives and uses thereof Dinucleoside poly(borano)phosphate derivatives and uses thereof

2008-05-06

2008-05-06

Crane, L. E. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S051000, C536S026220, C536S026260

Reexamination Certificate

active

07368439

ABSTRACT:
The present invention provides dinucleoside boranophosphate derivatives of the general formula I:wherein X and X′ each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y′ each independently is H or OH; Z1to Z5each independently is O−or BH3−, but excluding the compounds wherein Z1to Z5are each O−; W1to W4each independently is O, CH2, NH or C(Halogen)2; n and n′ each independently is 0 or 1; m is 3, 4 or 5; and M+represents a pharmaceutically acceptable cation, and to pharmaceutical compositions thereof. These dinucleoside boranophosphates are useful for prevention or treatment of diseases or disorders modulated by P2Y receptors such as type 2 diabetes, cystic fibrosis and cancer.

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