Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-02-28
1995-11-14
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 262, 536 245, 536 265, A61K 3170, C07H 2102, C07H 2104
Patent
active
054666775
ABSTRACT:
A dinucleotide analogue of formula ##STR1## where B.sup.1 and B.sup.2 are each independently a monovalent nucleoside base radical;
REFERENCES:
Padyukova et al. (I), "A New Synthetic Route to Phosphonate Analogs of 5'-Nucleotides," Bioorg. Khim., 13(5), 706-707 (1987); Chem. Abstr., 108(19), p. 691, Abstr. No. 167857v (1988).
Mikhailov et al., "Use of 5-Deoxy-ribo-hexofuranose Derivatives for the Preparation m of 5'-Nucleotide Phosphonates and Homoribonucleosides," Collect. Czech. Chem. Comm., 54, 1055-1066 (1989).
Padyukova et al. (II), "A New Scheme for the Synthesis of 5'-Nucleotide Phosphonte Analogs," Tett. Lett., 28(31), 3623-3626 (1987).
Breaker et al. "Synthesis and Properties of Adenosine Oligonucleotide Analogues Containing Methylene Groups in Place of Phosphodiester 5'-Oxygens," Biochemistry, 32(35), 9125-9128 (1993).
Marquez et al., "Thiazole-4-carboxamide Adenine Dinucleotide (TAD). Analogues Stable to Phosphodiesterase Hydrolysis," J. Med. Chem., 29(9), 1726-1731 (1986).
Buhr et al., "Methylenephosphonate Nucleoside Analogs and Oligonucleotide Analogs Made Therefrom," Chem. Abstr., 118(1), p. 780, Abstr. No. 7326z (1993); see patent reference L for the complete publication.
Baxter Anthony D.
Baylis Eric K.
Collingwood Stephen P.
De Mesmaeker Alain
Schmit Chantal
Ciba-Geigy Corporation
Crane L. Eric
Dohmann George R.
Robinson Douglas W.
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