Dinuclear platinum complexes as cisplatin analogs for cancer tre

Details Dinuclear platinum complexes as cisplatin analogs for cancer tre Dinuclear platinum complexes as cisplatin analogs for cancer tre

1998-10-26

2000-10-10

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

556137, A61K 3128

Patent

active

061302457

ABSTRACT:
This invention comprises the synthesis and the use of a new class of cisplatin analogs. These analogs are complexes formed between tetrachloroplatinum (II) and triethylenetetraamine or its derivatives. The stoichiometric ratio between cisplatin and triethylenetetraamine or its derivatives is between 0.4:1 to 0.5:0.8. The complexes are to be used in cancer treatment; they may also be used to treat AIDS patients.

REFERENCES:
patent: 4797393 (1989-01-01), Farrell
patent: 5107007 (1992-04-01), Farrell
CA:117:62087 abs of Platinum Other Met Coord Comp Cancer Chemother, (Proc Int Symp) 6th 1991, pp. 93-100 by Giandomenico.
CA:112:69485 abs of Byull. Eksp Biol Med by Plotnikov 108(9) pp. 313-315, 1989.
CA:108:179643 abs of J Antimicrob Chemother by Wondrak 21 (2), pp. 151-161, 1988.
CA:100:167839 abs of J Am Chem Soc by Vollano 106(9) pp. 2732-2733, 1984.
CA:93:179372 abs of Cancer Res by Crook 40 (9) pp. 3318-3324, 1980.

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