Dinuclear copper-based compound and ligand for nucleic acid...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Acyclic nitrogen double bonded to acyclic nitrogen – acyclic...

Reexamination Certificate

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Reexamination Certificate

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07365060

ABSTRACT:
The present invention is related to a novel method for splitting nucleic acids at specific points on a complementary nucleic acid segment using a dinuclear copper-based compound of Formula I. Additionally, the present invention is related to a novel treatment of cancer, tumors, and cancer cells using a dinuclear copper-based compound of Formula I or a naked ligand of formula II: (Formula I and II).

REFERENCES:
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Lee, Dong-Heon, et al. (“Binuclear Copper Complexes based on the 6,6′-Bis[[bis(2-pyridylmethyl)amino]methyl]-2,2′-bipyridine Ligand,” 1997 Inorganic Chem 36: 5785-5792).
Lee, Dong-Heon, et al. (“Reversible O2 binging to a dinuclear copper(I) complex with linked tris(2-pyridylmethyl)amine units,” 1995 JACS 117: 12498-12513).
Humphreys KJ, et al., “Targeted strand scission of DNA substrates by a Tricopper(II) coordination complex,” 2002 JACS 124: 8055-8066 (provided on PTO From 1449).
Humphreys KJ, et al., “Recognition and strand scission at junctions between single- and double-stranded DNA by a trinuclear copper complex,” 2001 JACS 123: 5588-5589 (provided on PTO From 1449).
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Kristi J. Humphreys et al; Recognition and Strand Scission at Junctions between Single-and Double-Stranded DNA by a Trinuclear Copper Complex; J. Am. Chem. Soc.; vol. 123; No. 23; 2001; pp. 5588-5589.
Kristi J. Humphreys et al; Targeted Strand Scission of DNA Substrates by a Tricopper (II) Coordination Complex; J. Am. Chem. Soc.; vol. 124; No. 27; 2001; pp. 8055-8066.
Kristi J. Humphreys et al; Efficient and Specific Strand Scission of DNA by a Dinuclear Copper Complex: Comparative Reactivity of Complexes with Linked Tris(2-pyridylmethyl)amine Moieties; J. Am. Chem. Soc. 2002; vol. 124; pp. 6009-6019.

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