Dimethyl-(3-aryl-but-3-enyl)-amine compounds as pharmaceutical a

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

560 64, 546290, 544162, 549 49, 549 74, 549467, 548182, 514653, 514533, 514345, 5142378, 514443, 514438, 514469, 514369, C07C21500, C07C 6976, A61K 31135, A61K 31235

Patent

active

058115820

ABSTRACT:
Dimethyl-(3-aryl-but-3-enyl)-amine compounds, a method of preparing them, and the use of the compounds as pharmaceutical active ingredients are described.

REFERENCES:
patent: 3956348 (1976-05-01), Hilscher
patent: 3978129 (1976-08-01), Welstead, Jr.
patent: 4173649 (1979-11-01), Sundeen et al.
patent: 4354154 (1982-10-01), Schiemann
patent: 4755599 (1988-07-01), Barriere et al.
patent: 5527821 (1996-06-01), Willman et al.
patent: 5539120 (1996-07-01), Griffith et al.
Dittert et al., "Acetaminophen Prodrugs I: Synthesis, Physicochemical Properties, and Analgesic Activity", Journal of Pharmaceutical Sciences, vol. 57, No. 5, May 1968, pp. 774-780.
Bundgaard et al., "A Novel Solution-Stable, Water-Soluble Prodrug Type for Drugs Containing a Hydroxyl or an NH-Acidc Group", Journal of Medicinal Chemistry, vol. 32, No. 12, Dec. 1989, pp. 2503-2507.
Welch, "Reduction of Aryl Diethyl Phosphates with Titanium Metal: A Method for Deoxygenation of Phenols", J. Org. Chem., vol. 43, No. 25, 1978, pp. 4797-4799.
Olofsson et al., Tetrahedron Letterss, No. 18, pp. 1571-1574, 1977.
Raffa et al., "Opioid and Nonopioid Components Independently Contribute to the Mechanism of Tramadol, an `Atypical` Opioid Analgesic", The Journal of Pharmacology and Experimental Therapeutics, vol. 260, No. 1, pp. 275-285, 1992.
Bundgaard, "Novel Chemical Approaches in Prodrug Design", Drugs of the Future, 1991, 16(5):443-458.
Thorberg et al., J. Med. Chem., vol. 30, No. 11, 1989, pp. 2008-2012.
Jaffe et al., "Chapter 21: Opioid Analgesics and Antagonists" and Jaffe, Chapter 22: Drug Addiction and Drug Abuse, Goodman and Gilman's: The Pharmacological Basis of Therapeutics, Eighth Edition, Pergamon Press, pp. 485-573, 1990.
Winterfeldt, "Applications of Diisobutylaluminum Hydride (DIBAH) and Triisobutylaluminium (TIBA) as Reducing Agents in Organic Synthesis", Synthesis, Oct. 1975, pp. 617-630.
Hilscher, "Splitting of Steroid Ethers", Chemical Abstracts, vol. 84, 1976, Abstract No 84: 59862v, p. 567.
Raffa et al., "Complementary and Synergistic Antinociceptive Interaction between the Enantiomers of Tramadol", Journal of Pharmacology and Experimental Therapeutics, vol. 267, No. 1, pp. 331-340, 1993.
Nazarov et al., Chemical Abstracts, vol. 54, No. 20, Oct. 20, 1960, Abstract No. 20963c.
Hendershot et al., "Antagonism of the Frequency of Phenylquinone-induced Writhing in the Mouse by Weak Analgesics and Nonanalgesics", The Biochemical Research Laboratory, The Dow Chemical Company, Midland, Michigan, Sep. 1958.
Flick et al., Arzneim. -Forsch./Drug Research, 28(1) 1978, pp. 107-113.
Maurer et al., Fresenius Z. Anal. Chem., (1984) 317:42-52.
Kato et al., Chem. Pharm. Bull.,32(6), pp. 2279-2289 (1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Dimethyl-(3-aryl-but-3-enyl)-amine compounds as pharmaceutical a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dimethyl-(3-aryl-but-3-enyl)-amine compounds as pharmaceutical a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dimethyl-(3-aryl-but-3-enyl)-amine compounds as pharmaceutical a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1622975

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.