Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-12-15
1984-10-09
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, C07C10352, A61K 3702
Patent
active
044761171
ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 stand for alk-2-enyl radicals of not more than 6 carbon atoms, A stands for Gly or Azgly, B stands for Leu or Met, J stands for --(CH.sub.2).sub.n --, wherein n stands for an integer from 1 to 10, or a phenylene radical, and pharmaceutically-acceptable acid-addition salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds are selective .delta.-opiate-receptor antagonists.
REFERENCES:
patent: 4221682 (1980-09-01), Sarantakis
patent: 4309343 (1982-01-01), Gesellchen
patent: 4320051 (1982-03-01), Sarantakis
patent: 4322342 (1982-03-01), Smithwick, Jr. et al.
patent: 4331593 (1982-05-01), Smithwick, Jr. et al.
Chemical Abstracts, 97, 84 (1982), Abst. No. 97:174912s.
Chemical Abstracts, 97, 171 (1982), Abst. No. 97:175692g.
Costa et al., (Abstract, 7th American Peptide Symposium, Madison, Wisconsin, U.S.A., Jun. 14-19, 1981).
Lipkowski and Konecka (Abstract, Peptides and their Receptors in the Central Nervous System, Hungarian and Polish Pharmacological Societies, 5th Joint Symposium, Zakopane, Poland, Oct. 3-4, 1981).
Hahn et al., Research Communications in Chemical Pathology and Pharmacology, 1977, 18 (1), pp. 1-9.
Imperial Chemical Industries plc
Moezie F.
Phillips Delbert R.
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