Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-12-17
2009-12-29
Kumar, Shailendra (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S359000, C514S381000, C514S616000
Reexamination Certificate
active
07638544
ABSTRACT:
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
REFERENCES:
patent: 7309792 (2007-12-01), Harran et al.
Carter et al, Chemotherapy of Cancer, Second edition, 1981, pp. 361-365.
De Brabander Jef K.
Harran Patrick G.
Li Lin
Suzuki Hidetaka
Thomas Ranny Mathew
Board of Regents , The University of Texas System
Kumar Shailendra
Osman Richard Aron
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