Dimeric non-azo naphthalimides and uses for same

Details Dimeric non-azo naphthalimides and uses for same Dimeric non-azo naphthalimides and uses for same

1995-06-07

1999-06-29

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 14, 546 13, 546 22, C07D47100, C07F 502, C07F 702, C07F 928

Patent

active

059170450

ABSTRACT:
A class of predominantly hydrophilic 1,8-naphthalimide dyes. The dye contains at least two 1,8-naphthalimide ring systems, joined by a spacer moiety. Each of the 1,8-naphthalimide ring system has a ring nitrogen atom and bears, at the 4 position, an amino nitrogen atom, carrying a hydrogen. The remaining unsatisfied valences, if present, of the ring nitrogen atoms or the amino nitrogen atoms, or all, are occupied by one or more alkyl substituents. Each of the 1,8-naphthalimide ring system is free of an azo substituent and is also free of a nucleofuge. Upon activation by an activating agent in an environment independent of the presence or absence of oxygen, these compounds generate activated species. The activated species can cause structural changes in lipid and any associated proteins and polypeptides, extra- or intra-cellular or transmembrane, leading to polymerization and crosslinking.

REFERENCES:
patent: 5235045 (1993-08-01), Lewis et al.
patent: 5561042 (1996-10-01), Weis et al.
patent: 5565551 (1996-10-01), Lewis
patent: 5604095 (1997-02-01), Weis et al.

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